The potential of engineered antibodies for HIV-1 therapy and cure

4Citations
Citations of this article
22Readers
Mendeley users who have this article in their library.

Abstract

Broadly neutralizing antibodies (bnAbs) are currently under investigation as a therapy for HIV-1 infection and recent clinical trials have shown prolonged viral suppression by bnAbs during antiretroviral treatment interruption. Interestingly, these bnAbs also showed the ability to activate the host immune system to clear HIV-1 infected cells. There are many possibilities to further increase the potential efficacy of bnAbs. Most notably, Fc domain engineering to improve half-life and increase engagement of effector cells will augment two advantages of bnAbs. Moreover, antibody engineering can improve affinity and recognition of conserved epitopes and allows the combination of multiple epitope specificities in a single molecule. These increasingly potent and broad antibodies may prove valuable as alternative HIV-1 therapeutic and possibly in curative approaches.

Cite

CITATION STYLE

APA

Grobben, M., Stuart, R. A., & van Gils, M. J. (2019, October 1). The potential of engineered antibodies for HIV-1 therapy and cure. Current Opinion in Virology. Elsevier B.V. https://doi.org/10.1016/j.coviro.2019.07.007

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free