Gating of Ca2+-activated K+ channels controls fast inhibitory synaptic transmission at auditory outer hair cells

181Citations
Citations of this article
68Readers
Mendeley users who have this article in their library.

Abstract

Fast inhibitory synaptic transmission in the central nervous system is mediated by ionotropic GABA or glycine receptors. Auditory outer hair cells present a unique inhibitory synapse that uses a Ca2+-permeable excitatory acetylcholine receptor to activate a hyperpolarizing potassium current mediated by small conductance calcium-activated potassium (SK) channels. It is shown here that unitary inhibitory postsynaptic currents at this synapse are mediated by SK2 channels and occur rapidly, with rise and decay time constants of ~6 ms and ~30 ms, respectively. This time course is determined by the Ca2+ gating of SK channels rather than by the changes in intracellular Ca2+. The results demonstrate fast coupling between an excitatory ionotropic neurotransmitter receptor and an inhibitory ion channel and imply rapid, localized changes in subsynaptic calcium levels.

Cite

CITATION STYLE

APA

Oliver, D., Klöcker, N., Schuck, J., Baukrowitz, T., Ruppersberg, J. P., & Fakler, B. (2000). Gating of Ca2+-activated K+ channels controls fast inhibitory synaptic transmission at auditory outer hair cells. Neuron, 26(3), 595–601. https://doi.org/10.1016/S0896-6273(00)81197-6

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free