Histopathologic changes in diseased tissues may render them inhospitable to engraftment by transplanted stem cells. A recent report in Nature Medicine (Gargioli et al., 2008) demonstrates that pretreatment of dystrophic mouse muscles with tissue-modifying factors leads to reduced fibrosis, increased vascularity, and enhanced stem cell engraftment. © 2008 Elsevier Inc. All rights reserved.
Rando, T. A. (2008, September 11). Turning Back Time: Reversing Tissue Pathology to Enhance Stem Cell Engraftment. Cell Stem Cell. https://doi.org/10.1016/j.stem.2008.08.006