A patient with PCO and primary infertility had undergone numerous failed attempts of ovulation induction. She then was treated with GnRHa leuprolide 500 μg subcutaneously daily for 4 weeks, later combined with hMG 225 IU IM daily for 8 days and hCG IU IM. Six oocytes were retrieved for IVF, four fertilized and two were replaced. Twin pregnancy was established and delivered at term. Hyperstimulation syndrome was managed conservatively.
Radwanska, E., Rawlins, R. G., Tummon, I., Maclin, V., Binor, Z., & Dmowski, W. P. (1988). Successful use of gonadotropin-releasing hormone agonist leuprolide for in vitro fertilization in a patient with polycystic ovarian disease and infertility unresponsive to standard treatment. Fertility and Sterility, 49(2), 356–359. https://doi.org/10.1016/S0015-0282(16)59728-3