Disturbances in the LIF pathway in the endometrium among women with unexplained infertility

44Citations
Citations of this article
24Readers
Mendeley users who have this article in their library.

Abstract

Objective: To study the expression of leukemia inhibitory factor (LIF), its receptors LIFR and gp130, and its inhibitor SOCS1 in endometria from fertile women and infertile women with unexplained infertility. Signaling through the LIF pathway is involved in maintenance of a receptive state of human endometrium. Impaired endometrial receptivity may be a cause of female infertility. Design: Prospective clinical study. Setting: Hospital-based IVF unit and university-affiliated reproductive research laboratories. Patient(s): Twenty-six healthy fertile women and 14 women with unexplained infertility. Intervention(s): Endometrial biopsy. Main Outcome Measure(s): Pinopode formation, expression of LIF, LIFR, gp130, and SOCS1 protein and mRNA in endometrial biopsies. Result(s): The expression of LIFR in the endometrium was negatively correlated to the expression of SOCS1 and positively correlated to the formation of pinopodes. In control fertile women, simultaneous intense apical staining of LIFR and gp130 together with faint SOCS1 staining was observed in epithelial cells, whereas the opposite was seen in most women with unexplained infertility. Conclusion(s): Unexplained infertility in some women might be explained by disturbances in the LIF pathway in midsecretory-phase endometrium. © 2009 American Society for Reproductive Medicine.

Cite

CITATION STYLE

APA

Aghajanova, L., Altmäe, S., Bjuresten, K., Hovatta, O., Landgren, B. M., & Stavreus-Evers, A. (2009). Disturbances in the LIF pathway in the endometrium among women with unexplained infertility. Fertility and Sterility, 91(6), 2602–2610. https://doi.org/10.1016/j.fertnstert.2008.04.010

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free