Intravenous immunoglobulin in the management of lupus nephritis

10Citations
Citations of this article
31Readers
Mendeley users who have this article in their library.

Abstract

The occurrence of nephritis in patients with systemic lupus erythematosus is associated with increased morbidity and mortality. The pathogenesis of lupus nephritis is complex, involving innate and adaptive cellular and humoral immune responses. Autoantibodies in particular have been shown to be critical in the initiation and progression of renal injury, via interactions with both Fc-receptors and complement. One approach in the management of patients with lupus nephritis has been the use of intravenous immunoglobulin. This therapy has shown benefit in the setting of many forms of autoantibody-mediated injury; however, the mechanisms of efficacy are not fully understood. In this paper, the data supporting the use of immunoglobulin therapy in lupus nephritis will be evaluated. In addition, the potential mechanisms of action will be discussed with respect to the known involvement of complement and Fc-receptors in the kidney parenchyma. Results are provocative and warrant additional clinical trials. © 2012 Scott E. Wenderfer and Trisha Thacker.

Cite

CITATION STYLE

APA

Wenderfer, S. E., & Thacker, T. (2012). Intravenous immunoglobulin in the management of lupus nephritis. Autoimmune Diseases. https://doi.org/10.1155/2012/589359

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free