RATIONALE: Increasing of the childhood allergic diseases throughout the world and its heavy socioeconomic burden have posed an important health concern. Therefore, providing the updated relevant epidemiological information is robustly recommended. We determined the prevalence of asthma, allergic rhinitis, and eczema symptoms in 6-7-year-old children of Tehran and ascertained the association between acetaminophen use, antibiotic consumption, as well as hospitalization for respiratory infection in early life and allergic symptoms. METHOD(S): Data were gathered by using a modified questionnaire of International Study of Asthma and Allergies in Childhood (ISAAC). Cluster sampling was used for random selection of primary schools. Then questionnaires (n=4993) were completed by the parents of children. RESULT(S): The prevalence of current wheeze, wheeze ever, current itching rash, itchy rash ever, and rhinitis ever were found 19.64%, 27.49%, 8.95%, 8.28%, and 21.87%, respectively. Physician-diagnosed asthma, eczema and allergic rhinitis were reported in 4.32%, 7.29%, and 9.61% of children, respectively. Univariate logistic regression analyses showed that acetaminophen and antibiotic use, and hospitalization for respiratory infection during the first year of life were all significantly associated (P<0.04) with symptoms of allergic diseases. Also the strongest association (P<0.03) was found between hospitalization due to respiratory infection in early life and allergic symptoms of children by multivariate analyses. CONCLUSION(S): This study determined the rising pattern of allergic symptoms in 6-7-year-old children of Tehran. Moreover, acetaminophen and antibiotic use, and hospitalization due to respiratory infection in early life were detected as significant risk factors in the appearance of childhood allergic symptoms.
Dana, V. G., Fazlollahi, M. R., Abbassi, J. M., Haghighat, S., & Yousefzade, A. (2017). Study of the Allergic Symptoms Prevalence and Some Relevant Factors Among School Children in Tehran. Journal of Allergy and Clinical Immunology, 139(2), AB26. https://doi.org/10.1016/j.jaci.2016.12.040