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Electron cryotomography of SARS-CoV-2 virions reveals cylinder-shaped particles with a double layer RNP assembly

Communications Biology (2022) 5(1)
DOI: 10.1038/s42003-022-04183-1
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Abstract

SARS-CoV-2 is a lipid-enveloped Betacoronavirus and cause of the Covid-19 pandemic. To study the three-dimensional architecture of the virus, we perform electron cryotomography (cryo-ET) on SARS-Cov-2 virions and three variants revealing particles of regular cylindrical morphology. The ribonucleoprotein particles packaging the genome in the virion interior form a dense, double layer assembly with a cylindrical shape related to the overall particle morphology. This organisation suggests structural interactions important to virus assembly.

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APA

Calder, L. J., Calcraft, T., Hussain, S., Harvey, R., & Rosenthal, P. B. (2022). Electron cryotomography of SARS-CoV-2 virions reveals cylinder-shaped particles with a double layer RNP assembly. Communications Biology, 5(1). https://doi.org/10.1038/s42003-022-04183-1

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