Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer

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Abstract

Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/+ heterozygous cells, or Rp/+ heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.

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Baker, N. E., & Kale, A. (2016). Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer. Molecular and Cellular Oncology, 3(1). https://doi.org/10.1080/23723556.2015.1029065

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