Farmacogenômica e Doença Cardiovascular: Onde Estamos e Para Onde Vamos

Abstract

Pharmacogenomics (PGx) studies the interaction between genes and drugs. By analysis of specific regions of DNA, it is possible to obtain information on patient’s metabolization profile of a given drug, as well as the expected profile of response to treatment. The results obtained are allies in the treatment of patients who are not responding adequately to a certain medication, either due to the lack of expected effects or presence of adverse effects. The aim of this review is to inform clinical cardiologists about this important area of knowledge and to update them on the topic, seeking to fill the gaps of the costs and benefits of PGx in cardiovascular diseases, and to provide information for the implementation of PGx-guided therapy in clinical practice.