Analysis of antigenic diversity among human cytomegaloviruses by kinetic neutralization tests with high titered rabbit antisera

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Abstract

Neutralizing antisera to human cytomegalovirus were produced in rabbits with alkaline-buffered extracts of infected cell cultures. The antibody activity was complement dependent and associated primarily with the 7S immunoglobulin fraction. Antisera with homologous K values greater than 10,000 were shown to be suitable for neutralization kinetic studies and were so used to examine the antigenic relatedness of strains AD169, Davis, Esp, C-87, Kerr, and Towne. Based upon the degree of relationship as determined by normalized K values, antisera to the Davis or AD169 strains discriminated 3 antigenic groups, and an antiserum to strain Esp discriminated 2 groups.

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Waner, J. L., & Weller, T. H. (1978). Analysis of antigenic diversity among human cytomegaloviruses by kinetic neutralization tests with high titered rabbit antisera. Infection and Immunity, 21(1), 151–157. https://doi.org/10.1128/iai.21.1.151-157.1978

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