Xeroderma Pigmentosum Groups C and F: Additional Assignments and A Review of the Subjects in Japan

Abstract

The differential bead-labelling method for heterodikaryon complementation enabled us to allocate xeroderma pigmentosum patients XP40KO and XP38KO to complementation groups C and F, respectively Group C XP40KO cells exhibited 15% UDS and the 5 and 1.5-fold hypersenstivities to UV and 4-nitrO’ quinoline-1-oxide (4NQO) killings, respectively, while group F XP38KO cells showed a higher residual level of 20-25% UDS and a less UV/4NQO hypersensitivity than did the previously assigned group F strains. We reviewed the thus far assigned Japanese groups C and F subjects for the repair and clinical characteristics. The present group C XP40KO was typical, while XP38KO was heterogrnous within group F with respect tc repair. © 1985, Journal of Radiation Research Editorial Committee. All rights reserved.