Bioactive compounds from marine yeast inhibits lung cancer

Abstract

Anticancer agents derived from natural products such as various sources like plants, animals and microorganisms. Marine-derived microorganism has become important sources of new bioactive molecules. Theproducts isolated from marine sources possess cytotoxic activities against many cancers. Secondary metabolitesas a source of Candida albicans natural drugs many of the medicines prescribed today are natural productsobtained from terrestrial plants and microorganisms. The major components (80-90%) of cell wall of arecarbohydrates, mannose or polymers of mannose covalently associated with proteins to form glycoproteins. TheAmerican Cancer Society has estimated 159,260 deaths due to lung cancer from diagnosis of 224,210 new casesin the United States in 2014. The International Agency for Research on Cancer estimated over 1 million newcancers cases in India in 2012 (10, 14, 934). In this study, we aimed to find new bioactive compounds from crudeculture extracts produced by C. albicans as isolated from coastal mangrove ecosystem and docking studies werecarried out.