Abstract
Three new withanolides, coagulins M, N, and O were isolated from the whole plant of Withania coagulans. Their structures were established as (14R,17R,20ζ,22R)-5α,6β,27-trihydroxy-14,20-epoxy-1-oxo-witha-24-enolide (1), (14R,17S,20ζ,22R)-15α,17-dihydroxy-14,20-epoxy-3β-(O-β-D- glucopyranosyl)-1-oxo-witha-5,24-dienolide (2) and (14R,20ζ,22R)-14,20- dihydroxy-3β-(O-Dβ-D-glucopyranosyl)-1-oxo-witha-5,24-dienolide (3) respectively, by extensive spectroscopic studies.
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Atta-Ur-Rahman, Iqbal Choudhary, M., Yousaf, M., Gul, W., & Qureshi, S. (1998). New withanolides from Withania coagulans. Chemical and Pharmaceutical Bulletin, 46(12), 1853–1856. https://doi.org/10.1248/cpb.46.1853
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