Freeing Yeast from Alcohol Addiction (Just) to Make (It) Fat Instead

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Abstract

Synthetically re-designing eukaryotic metabolism has proven immensely challenging, raising the question of whether evolution has metabolically hardwired eukaryotic cells. Yu et al. now report that, through orchestrating multiple genetic changes and laboratory evolution, Saccharomyces metabolism can be reprogrammed from its evolutionary objective of producing ethanol to produce large amounts of free fatty acids. Synthetically re-designing eukaryotic metabolism has proven immensely challenging, raising the question of whether evolution has metabolically hardwired eukaryotic cells. Yu et al. now report that, through orchestrating multiple genetic changes and laboratory evolution, Saccharomyces metabolism can be reprogrammed from its evolutionary objective of producing ethanol to produce large amounts of free fatty acids.

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Patil, K. R., & Ralser, M. (2018, September 6). Freeing Yeast from Alcohol Addiction (Just) to Make (It) Fat Instead. Cell. Cell Press. https://doi.org/10.1016/j.cell.2018.08.024

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