Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus

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Abstract

Objective To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection. Methods We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy. Results Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion. Conclusions New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.

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Puoti, M., Lorenzini, P., Cozzi-Lepri, A., Gori, A., Mastroianni, C., Rizzardini, G., … Baldin, G. (2017). Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus. Clinical Microbiology and Infection, 23(4), 267.e1-267.e4. https://doi.org/10.1016/j.cmi.2016.12.003

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