The excess use of nimesulide (NIM) causes acute side effects to gastrointestinal, central nervous and genitourinary systems and hence its rapid, sensitive determination is highly important. We describe a robust electrochemical sensor based on electrochemically reduced graphene oxide nanoribbons (ER-GONRs) modified on a screen-printed carbon electrode (SPCE) for detecting NIM in pharmaceutical formulations and biological medium. Compared with parental multiwalled carbon nanotubes (MWCNTs), ER-GONRs possess rich edge defects, abundant functional groups, high area-normalized edge-plane structures and chemically active sites and hence they can be a superior electrocatalyst and signal amplifier for electroanalytical applications. ER-GONRs/SPCE exhibited excellent sensing performance towards NIM. The linear range was 1.0 × 10-8 to 1.50 × 10-3 M and the detection limit was 3.50 (±1.57) nM. In addition, the ER-GONRs/SPCE showed excellent real-time sensing applications in NIM tablet and human urine samples, which could find potential applicability in drug and clinical analysis. The combined advantages of SPCE technology and ER-GONRs make this method a robust, low-cost, reproducible, sensitive and easy-to-use sensor.
Govindasamy, M., Mani, V., Chen, S. M., Maiyalagan, T., Selvaraj, S., Chen, T. W., … Chang, W. H. (2017). Highly sensitive determination of non-steroidal anti-inflammatory drug nimesulide using electrochemically reduced graphene oxide nanoribbons. RSC Advances, 7(52), 33043–33051. https://doi.org/10.1039/c7ra02844j