A fibrinogen-binding protein of Staphylococcus lugdunensis

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Abstract

A gene called fbl, encoding a Staphylococcus lugdunensis fibrinogen-binding protein, was identified by phage display. The encoded protein, Fbl, is a member of the Sdr-family, a group of staphylococcal cell surface proteins containing a characteristic serine-aspartate repeat region. The fibrinogen-binding domain was mapped to 313 amino acids, and shows 62% identity to the corresponding region in clumping factor (ClfA) from Staphylococcus aureus. Anti-serum against ClfA cross-reacted with Fbl, and blocked S. lugdunensis adherence to fibrinogen. Twelve clinical isolates of S. lugdunensis analysed by Southern blot all had an fbl-like gene. © 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

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Nilsson, M., Bjerketorp, J., Guss, B., & Frykberg, L. (2004). A fibrinogen-binding protein of Staphylococcus lugdunensis. FEMS Microbiology Letters, 241(1), 87–93. https://doi.org/10.1016/j.femsle.2004.10.008

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