Near-infrared spectroscopy parameters in patients undergoing continuous venovenous hemodiafiltration

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Abstract

OBJECTIVE: To investigate the impacts of continuous venovenous hemodiafiltration on the microcirculation in patients with acute kidney injury. METHODS: A prospective observational pilot study conducted in a 40-bed, open clinical-surgical intensive care unit of a private tertiary care hospital located in the city of São Paulo (SP), Brazil. Microcirculation was assessed using near-infrared spectroscopy by means of a 15mm probe placed over the thenar eminence. Vascular occlusion test was performed on the forearm to be submitted to near-infrared spectroscopy by inflation of a sphygmomanometer cuff to 30mmHg higher than the systolic arterial pressure. The primary endpoint was the assessment of near-infrared spectroscopy-derived parameters immediately before, 1, 4 and 24 hours after the initiation of continuous venovenous hemodiafiltration. RESULTS: Nine patients were included in this pilot study over a period of 2 months. Minimum tissue oxygen saturation measured during the vascular occlusion test was the only near-infrared spectroscopy-derived parameter to differed over the time (decrease compared to baseline values up to 24 hours after initiation of continuous venovenous hemodiafiltration). CONCLUSION: The impacts of microcirculatory dysfunction on clinical outcomes of patients undergoing to continuous venovenous hemodiafiltration need to be further investigated.

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Chaves, R. C. de F., Tafner, P. F. do A., Chen, F. K., Meneghini, L. B., Corrêa, T. D., Rabello Filho, R., … Serpa Neto, A. (2019). Near-infrared spectroscopy parameters in patients undergoing continuous venovenous hemodiafiltration. Einstein (Sao Paulo, Brazil), 17(1), eAO4439. https://doi.org/10.31744/einstein_journal/2019AO4439

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