Pulmonary hypertension-"state of the art" management in 2012

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Abstract

Pulmonary artery hypertension (PAH) is a pathological condition of small pulmonary arteries, characterised by vascular proliferation and remodelling. The pulmonary artery pressure and pulmonary vascular resistance progressively rise, leading to right heart failure and death. Pulmonary artery hypertension may be secondary to various conditions, or it may be idiopathic where no underlying cause is identifiable. Earlier, only symptomatic treatment was available for such patients which did not change the natural history of the disease. However, over the years, improvement in understanding the pathogenesis has resulted in the development of targeted approaches to the treatment of PAH. Survival advantage has also been shown with some of the pharmacologic agents. This review article discusses the current management strategy for PAH with special emphasis on an idiopathic variety, in an Indian context. © 2012. Cardiological Society of India. All rights reserved.

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Saxena, A. (2012). Pulmonary hypertension-"state of the art" management in 2012. Indian Heart Journal. Elsevier B.V. https://doi.org/10.1016/S0019-4832(12)60013-3

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