Objective: To determine if screening family members of patients with acute brucellosis will enhance the detection rate of brucellosis and also to determine the relationship between symptoms and brucella serology. Materials and methods: Family members from patients with acute brucellosis were interviewed and serologically screened. All seropositive family members were clinically and serologically followed for six months. Results: Twenty-five acute brucellosis patients and their 178 family members were enrolled from January 2001 to February 2002. Of the 178 family members, 40 (23%) manifested various symptoms, 138 (77%) were asymptomatic, with an overall seroprevalence rate of 34 (19%). The rate of seropositivity among the symptomatic family members was 23 (58%) and for the asymptomatic was 11 (8%) (P < 0.001). The majority of the symptomatic family members (13 (57%)) had a high Brucella titer in comparison to one (9%) of the asymptomatic group (P < 0.001). Acute brucellosis was diagnosed and treated in 18 (78%) of the symptomatic seropositive family members and in four (36%), of the asymptomatic seropositive family members with an acute brucellosis prevalence rate of 22 (12%). All family members with acute infection recovered without sequelae; one patient relapsed (5%). Conclusion: Symptomatic family members are more likely to be seropositive with a high titer in comparison to the asymptomatic members. © 2005 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Alsubaie, S., Almuneef, M., Alshaalan, M., Balkhy, H., Albanyan, E., Alola, S., … Memish, Z. A. (2005). Acute brucellosis in Saudi families: Relationship between brucella serology and clinical symptoms. International Journal of Infectious Diseases, 9(4), 218–224. https://doi.org/10.1016/j.ijid.2004.07.009