Strain rate echocardiography uncovers subclinical left ventricular dysfunction in cystic fibrosis

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Abstract

Background: CFTR is expressed in cardiac myocytes. In mice, lack of CFTR alters cardiomyocyte contraction and Ca2+ signaling, and decreases cardiac reserve. We undertook a pilot study evaluating left ventricular (LV) function in CF patients using strain and strain rate echocardiography. Methods: Echocardiography with tissue Doppler and strain and strain rate imaging were performed in 8 CF adults following pulmonary function tests. Results were compared to literature values obtained in healthy subjects. Results: All CF individuals had normal LV ejection fractions. In contrast, 50% of men and 100% of women with CF had decreased LV systolic strain. Strain rates were significantly decreased in 100% of CF individuals. RV function was normal and LV function did not correlate with lung function. Conclusions: Strain and strain rate echocardiography identified LV systolic abnormalities in CF individuals not detected by conventional echocardiography. We propose that this echocardiography modality may identify subclinical cardiac dysfunction in CF.

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Sellers, Z. M., McGlocklin, L., & Brasch, A. (2015). Strain rate echocardiography uncovers subclinical left ventricular dysfunction in cystic fibrosis. Journal of Cystic Fibrosis, 14(5), 654–660. https://doi.org/10.1016/j.jcf.2015.03.010

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