This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the effectiveness of intratracheal administration of synthetic protein-free pulmonary surfactant in neonates at risk of developing RDS or with established RDS. Comparison 1: Does intratracheal administration of synthetic protein-free pulmonary surfactant compared to air placebo or normal saline or no treatment reduce mortality and other complications of preterm birth in preterm infants at risk of developing RDS? Comparison 2: Does intratracheal administration of synthetic protein-free pulmonary surfactant compared to air placebo or normal saline or no treatment reduce mortality and other complications of preterm birth in preterm infants with clinical and/or radiologic evidence of respiratory distress syndrome requiring assisted ventilation?
CITATION STYLE
Lasalvia, P., Buitrago Lopez, A., Rojas-Reyes, M. X., Özek, E., & Soll, R. (2017). Protein-free synthetic surfactant for the prevention and treatment of respiratory distress syndrome in neonates. Cochrane Database of Systematic Reviews, 2017(10). https://doi.org/10.1002/14651858.CD012821
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