Effect of rutin and its copper complex on superoxide formation and lipid peroxidation in rat liver microsomes

26Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

Two free radical scavengers, bioflavonoid rutin and the copper-rutin complex CuO(Rut)Cl2, inhibited lucigenin-amplified chemiluminescence and lipid peroxidation in rat liver microsomes, Cu(Rut)Cl2 being a 5-9 times more efficient inhibitor than rutin. The enhanced inhibitory activity of Cu(Rut)Cl2 was due to the presence of the additional superoxide-dismutating center (Cu), as follows from the comparison of its effects on microsomal chemiluminescence and cytochrome c reduction by xanthine oxidase. Similar effects of both inhibitors on superoxide production and lipid peroxidation as well as the elevated activity of Cu(Rut)Cl2 indicate an important role of superoxide ion in the initiation of microsomal lipid peroxidation.

Cite

CITATION STYLE

APA

Afanas’Ev, I. B., Ostrachovich, E. A., & Korkina, L. G. (1998). Effect of rutin and its copper complex on superoxide formation and lipid peroxidation in rat liver microsomes. FEBS Letters, 425(2), 256–258. https://doi.org/10.1016/S0014-5793(98)00244-0

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free