Clinical use of Aglepristone for treatment of open-cervix pyometra in cats

Abstract

The results of the clinical application of the integrated therapy of cats having an open-cervix of the pyometra are presented in this work. It has been proved that pathology affects mostly the animals in the age from 3 to 8 years. In the clinical study, it was found that in the open-cervix of the pyometra cats had also depression, anorexia, polydipsia, polyuria, increase in the abdomen, withdrawal of the purulent exudate from the vagina. In micropreparations taken from the vaginal mucosa, an increase in the number of neutrophilic granulocytes was observed, most of them with signs of apoptosis. Significant changes in functional reactivity of phagocytic cells were found. Using microbiological researches the polymicrobial association of pathogenic microorganisms have been identified in the exudate. Hematologic studies have shown decrease of hemoglobin content and signs of neutrophilic leukocytosis. In ultrasonography, patients with pyometra showed an increase in the body and horns of the uterus, which were stretched with accumulated fluid, thickening of the organ's wall, and a clear picture of the cystic endometrial hyperplasia of the endometrium was visualized. The research has tested a treatment regimen with the use of Aglepristone (Alizin® Virbac, France) in combination with Mastometrin and antibiotic therapy (Amoscillin 15%, INVESA, Spain). During the treatment the fever, vomiting and polydipsia have disappeared, the appetite hat restored. Laboratory studies have established a dynamic reduction in the number of leukocytes and fading reactive neutrophilia. The ultrasound has noted decreased diameter of the uterus. Major hematological and immunological parameters of homeostasis were normalized. The obtained clinical studies indicate that the complex scheme of therapy of cats for the open-cervix of the pyometra contributes to the restoration of the functional state of the uterus, the extinction of the pathological process and the normalization of the functions of all organs and systems.