Abstract
An association between Parkinson’s disease (PD) and brain-derived neurotrophic factor (BDNF) was suggested by several studies, with contradictory results. BDNF is necessary for the survival of dopaminergic neurons in substantia nigra. Val66Met is a common polymorphism of the BDNF gene that affects cognitive and motor processes. The authors studied 104 Brazilian patients with PD and 96 control participants. The G/G genotype was significantly associated with depression and anxiety symptoms and development of PD. This is the first study that associates this genotype with PD.
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CITATION STYLE
Cagni, F. C., Campêlo, C. L. das C., Coimbra, D. G., Barbosa, M. R., Oliveira Júnior, L. G., Neto, A. B. S., … Silva, R. H. (2017). Association of BDNF Val66MET polymorphism with Parkinson’s disease and depression and anxiety symptoms. Journal of Neuropsychiatry and Clinical Neurosciences, 29(2), 142–147. https://doi.org/10.1176/appi.neuropsych.16040062
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