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Inflammation in areas of fibrosis

  • Matas A
  • Helgeson E
  • Gaston R
  • et al.
ISSN: 1600-6135
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Abstract

Inflammation in areas of fibrosis (i-IFTA) in posttransplant biopsy specimens has been associated with decreased death-censored graft survival (DC-GS). Additionally, an i-IFTA score???????2 is part of the diagnostic criteria for chronic active TCMR (CA TCMR). We examined the impact of i-IFTA and t-IFTA (tubulitis in areas of atrophy) in the first biopsy for cause after 90??days posttransplant (n??=??598); mean (SD) 1.7??????1.4??years posttransplant. I-IFTA, present in 196 biopsy specimens, was strongly correlated with t-IFTA, and Banff i. Of the 196, 37 (18.9%) had a previous acute rejection episode; 96 (49%) had concurrent i score??=??0. Unlike previous studies, i-IFTA??=??1 (vs 0) was associated with worse 3-year DC-GS: (i-IFTA??=??0, 81.7%, [95% CI 77.7 to 85.9%]); i-IFTA??=??1, 68.1%, [95% CI 59.7 to 77.6%]; i-IFTA??=??2, 56.1%, [95% CI 43.2 to 72.8%], i-IFTA??=??3, 48.5%, [95% CI 31.8 to 74.0%]). The association of i-IFTA with decreased DC-GS remained significant when adjusted for serum creatinine at the time of the biopsy, Banff i, ci and ct, C4d and DSA. T-IFTA was similarly associated with decreased DC-GS. Of these indication biopsies, those with i-IFTA???????2, without meeting other criteria for CA TCMR had similar postbiopsy DC-GS as those with CA TCMR. Those with i-IFTA??=??1 and t???????2, ti???????2 had postbiopsy DC-GS similar to CA TCMR. Biopsies with i-IFTA??=??1 had similar survival as CA TCMR when biopsy specimens also met Banff criteria for TCMR and/or AMR. Studies of i-IFTA and t-IFTA in additional cohorts, integrating analyses of Banff scores meeting criteria for other Banff diagnoses, are needed.

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APA

Matas, A. J., Helgeson, E. S., Gaston, R., Cosio, F., Mannon, R., Kasiske, B. L., … Grande, J. P. (2020). Inflammation in areas of fibrosis. American Journal of Transplantation. Retrieved from https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85083427612&origin=inward

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