A possible role of vimentin on the cell surface for the activation of latent transforming growth factor-β

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Abstract

Latent TGF-β (LTGF-β) has to be converted to active TGF-β for its activities. Previously, we reported that certain fragments of latency associated peptide (LAP) augmented LTGF-β activation via increase in binding of LTGF-β to the endothelial cell (EC) surface followed by cell-associated proteolysis. By searching for EC membrane proteins crosslinked with the LAP fragment, we identified the molecule bound to LAP fragment as vimentin. Moreover, the LAP fragment-induced LTGF-β activation was attenuated by anti-vimentin antibody. These results indicate that binding of the LAP fragment to vimentin on the cell surface is indispensable for LTGF-β activation by the LAP fragment. Structured summary: MINT-6806227:. vimentin (uniprotkb:P48616) binds (MI:0407) to LAP (uniprotkb:P18341) by competition binding (MI:0405). MINT-6806183:. LAP (uniprotkb:P18341) binds (MI:0407) to vimentin (uniprotkb:P48616) by cross-linking studies (MI:0030). © 2008 Federation of European Biochemical Societies.

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Nishida, Y., Shibata, K., Yamasaki, M., Sato, Y., & Abe, M. (2009). A possible role of vimentin on the cell surface for the activation of latent transforming growth factor-β. FEBS Letters, 583(2), 308–312. https://doi.org/10.1016/j.febslet.2008.12.051

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