Potential drug interactions in medical prescriptions containing restricted use antimicrobial, for patients in a hospital within the Bahia

Abstract

Study model: Quantitative, descriptive study, with a cross-sectional design, conducted in 2013. Objective: Conduct an assessment of potential drug interactions (PDI) in medical prescriptions containing restricted use antimicrobial in patients in a hospital within the Bahia. Methodology: Data was collected from January to May through document analysis, with prospective monitoring of prescriptions contained in the medical records in order to enable the detection of PDI. The occurrence and classification of PDI were verified through the MICROMEDEX DrugReax® System database. Results: 50 patients participated in the study, which analyzed 797 medical prescriptions. Amongst the group of restricted use antimicrobials, the combination piperacillin + tazobactam was the most prescribed being present in 33.0% of prescriptions. From the prescriptions used for analysis of the PDI, 357 (46.5%) had at least one potential drug interactions, and of these, 7 (5.8%) involved the restricted use antimicrobials. The following drugs were found involved with PDI: amytriptiline + linezolid (46.0%), piperacillin + warfarin (26.0%), among others. Of the total interactions found, 467 (31.9%) were classified as mild and good documentation, 808 (53.5%) as interactions of pharmacokinetic mechanism of action and 743 (50.8%) as interactions of delayed reaction start. Conclusion: A review of the PDI was performed in containing antimicrobial prescriptions for restricted use, and from them a table of aid was organized with input for the rational use of some antimicrobials which are potentially involved in drug interactions.