Histology and histochemistry of the aging cerebral cortex: An overview

Abstract

This review contributes to a new vision of the most important findings in the aging cerebral cortex as elucidated by modern histology and histochemistry. It includes an overview of the macroscopic and microscopic changes involved, not only in normal aging, but also in the main age-related neurodegenerative diseases. Finally, the most accepted theories about aging as well as the implications of nitric oxide in this process are described.