INTRODUCTION AND OBJECTIVES: To characterize the subject experience and evaluate early response to the Prostatic Urethral Lift (PUL) through a multi-center, prospective, non-randomized study. METHODS: 51 men with AUASI > 12, Qmax +/- 12mL/s, and prostate volume < 80 cc were treated with PUL at 7 US centers. PUL involves placing permanent transprostatic UroLift implants into the lateral lobes of the prostate to enlarge the urethral lumen. Patient experience during the procedure was captured at specific points through a pelvic pain visual analog scale. Post operative experience was measured via validated instruments Quality of Recovery VAS (QOR), Patient General Impression Index (PGI-I), Work Productivity and Activity Impairment Questionnaire (WPAI), AUA Symptom Index (AUASI), AUASI Quality of Life (QoL), Benign Prostatic Hyperplasia Impact Index (BPH II), as well as urinary flow rate, sexual function, and adverse events. RESULTS: All procedures were completed with local anesthesia. Adverse events related to PUL were typically mild to moderate and resolved by 2 weeks. There were no reported occurrences of ejaculatory or erectile dysfunction. By one month, 86% of subjects were recovered (>80 QOR), 90% reported improvement through PGI-I, 96% had returned to pre-operative activity, 100% of employed subjects had returned to work, and 75% of subjects would recommend the procedure to a friend. Subjects experienced improvement in AUASI (10.5), QoL (2.1), and BPH II (3.4) at one month assessment (p-Values < 0.001, Table 1). Peak urinary flow rate (Qmax) improved 3.1 ml/s (Table 1). Average erectile function scores did not change significantly, and both ejaculatory function and bother were improved (Table 1). CONCLUSIONS: PUL is tolerated under local anesthesia and can allow patients to quickly return to pre-operative activity. The procedure may provide rapid symptom relief and objective flow improvements while preserving sexual function. (Table Presented).
Shore, N., Freedman, S., Gange, S., Moseley, W., Heron, S., Brown, B. T., & Tutrone, R. (2014). MP71-07 PROSPECTIVE SINGLE ARM STUDY TO CHARACTERIZE PROSTATIC URETHRAL LIFT PATIENT EXPERIENCE. Journal of Urology, 191(4S). https://doi.org/10.1016/j.juro.2014.02.2166