EMPhasis on Mutant Microglia: Dysregulation of Brain Sentinels Induces Neurodegeneration

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Abstract

Reactive microglia are often implicated in the pathology of neurodegenerative disease. In a recent study in Nature, Mass et al. (2017) demonstrate that targeted mutation of Braf in early erythro-myeloid precursors (EMPs) causes histiocytosis-associated late onset neurodegeneration driven by activated microglia. Reactive microglia are often implicated in the pathology of neurodegenerative disease. In a recent study in Nature, Mass et al. (2017) demonstrate that targeted mutation of Braf in early erythro-myeloid precursors (EMPs) causes histiocytosis-associated late onset neurodegeneration driven by activated microglia.

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Schreiner, B., & Greter, M. (2017, November 2). EMPhasis on Mutant Microglia: Dysregulation of Brain Sentinels Induces Neurodegeneration. Cell Stem Cell. Cell Press. https://doi.org/10.1016/j.stem.2017.10.006

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