Control of viral replication after cessation of HAART

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Abstract

We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual secondary controller status. But their viruses are clearly less fit compared to viruses from rebounders. © 2011 Van Gulck et al; licensee BioMed Central Ltd.

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Van Gulck, E., Heyndrickx, L., Bracke, L., Coppens, S., Florence, E., Buvé, A., … Vanham, G. (2011). Control of viral replication after cessation of HAART. AIDS Research and Therapy, 8. https://doi.org/10.1186/1742-6405-8-6

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