Preparation of pesticide microspheres based on polylactic acid: Optimized by response surface methodology

Abstract

Polylactic acid, as a kind of environment-friendly material, has excellent biodegradability, biocompatibility and plasticity. In recent years, it has been widely used in medicine, packaging and other fields, but rarely in agriculture. In this study, the process of buprofezin - polylactic acid microsphere was optimized by response surface method. Changing parameters, especially the concentration of PLA and the PLA/drug ratio, can increase the encapsulation efficiency of buprofezin - PLA microspheres. Ultimately, the highest encapsulation efficiency reached to 96.47%. The result of FESEM and laser particle size distribution analyzer showed that the microspheres have smooth surface and good dispersion, with particle size of 34.2 μm.