Myxothiazol: A reversible blocker of the cell cycle

Abstract

Myxothiazol, a potent inhibitor of the cytochrome bc1 oxidoreductase, was shown by the use of flow cytometry to block reversibly the late G1/S phase of the cell cycle of human lymphoblastic T-cell line Jurkat (clone 886) at concentrations of 0.5 μ/ml. These observations are compared to those of other drugs, such as antimycin which effect the respiratory chain, and with O2-deficiency. © 1989, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.