Modification of cullin-RING ubiquitin ligases by the ubiquitin-like molecule Nedd8 promotes substrate ubiquitination. A crystal structure of a cullin modified by Nedd8 recently reported in Cell (Duda et al., 2008) and a biochemical study in Molecular Cell (Saha and Deshaies, 2008) reveal the dramatic impact on the ligase machinery by conjugation of ubiquitin or ubiquitin-like proteins. © 2008 Elsevier Inc. All rights reserved.
Saifee, N. H., & Zheng, N. (2008, October 17). A Ubiquitin-like Protein Unleashes Ubiquitin Ligases. Cell. https://doi.org/10.1016/j.cell.2008.09.049