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Exercise can improve cognitive function and the outcome of neurodegenerative diseases like Alzheimer’s disease. This effect has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Recently, we have reported a PGC-1α-FNDC5/irisin pathway that is activated by exercise in the hippocampus in mice and induces a neuroprotective gene program, including Bdnf. This review will focus on FNDC5 and its secreted form “irisin,” a newly discovered myokine, its role in the nervous system and its therapeutic potential. In addition, we will briefly discuss the role of other exercise-induced myokines in positive brain effects.
Islam, M. R., Young, M. F., & Wrann, C. D. (2017). The role of FNDC5/Irisin in the nervous system and as a mediator for beneficial effects of exercise on the brain. In Research and Perspectives in Endocrine Interactions (pp. 93–102). Springer Verlag. https://doi.org/10.1007/978-3-319-72790-5_8