Efficacy of flow restrictors in limiting access of liquid medications by young children

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Objective To assess whether adding flow restrictors (FRs) to liquid medicine bottles can provide additional protection against unsupervised medication ingestions by young children, even when the child-resistant closure is not fully secured. Study design In April and May 2012, we conducted a block randomized trial with a convenience sample of 110 3- and 4-year-old children from 5 local preschools. Participants attempted to remove test liquid from an uncapped bottle with an FR and a control bottle without an FR (with either no cap or an incompletely closed cap). Results All but 1 (96%; 25 of 26) of the open control bottles and 82% (68 of 83) of the incompletely closed control bottles were emptied within 2 minutes. Only 6% (7 of 110) of the bottles with FRs were emptied during the 10-minute testing period, none before 6 minutes. Overall, children removed less liquid from the bottles with FRs than from the open or incompletely closed control bottles without FRs (both P <.001). All children assigned open control bottles and 90% of those assigned incompletely closed control bottles removed ≥25 mL of liquid. In contrast, 11% of children removed ≥25 mL of liquid from uncapped bottles with FRs. Older children (aged 54-59 months) were more successful than younger children at removing ≥25 mL of liquid (P =.002) from bottles with FRs. Conclusion Our findings suggest that adding FRs to liquid medicine bottles limits the accessibility of their contents to young children and could complement the safety provided by current child-resistant packaging. Copyright © 2013 Mosby Inc. All rights reserved.




Lovegrove, M. C., Hon, S., Geller, R. J., Rose, K. O., Hampton, L. M., Bradley, J., & Budnitz, D. S. (2013). Efficacy of flow restrictors in limiting access of liquid medications by young children. Journal of Pediatrics, 163(4). https://doi.org/10.1016/j.jpeds.2013.05.045

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