Insulin analogues.

Abstract

Development of the insulin analogues has made it possible to reproduce much more accurately the physiologic insulin profiles seen in people who do not have diabetes. The rapidacting analogues, such as insulin aspart and insulin lispro, offer improved postprandial glycemic control and reduced risk of hypoglycemia. The long-acting analogues, such as insulin glargine and insulin detemir, mimic the insulin secretory profile of basal insulin. Together, they approximate physiologic insulin secretion.