Incidence and short-term mortality from perforated peptic ulcer in Korea: A population-based study

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Abstract

Background: Perforated peptic ulcer (PPU) is associated with serious health and economic outcomes. However,few studies have estimated the incidence and health outcomes of PPU using a nationally representative sample in Asia. We estimated age- and sex-specific incidence and short-term mortality from PPU among Koreans and investigated the risk factors for mortality associated with PPU development. Methods: A retrospective population-based study was conducted from 2006 through 2007 using the Korean National Health Insurance claims database. A diagnostic algorithm was derived and validated to identify PPU patients, and PPU incidence rates and 30-daymortality rates were determined. Results: From 2006 through 2007, the PPU incidence rate per 100 000 population was 4.4; incidence among men (7.53) was approximately 6 times that among women (1.24). Incidence significantly increased with advanced age,especially among women older than 50 years. Among 4258 PPU patients, 135 (3.15%)died within 30 days of the PPU event. The 30-day mortality rate increased with advanced age and reached almost 20% for patients older than 80 years. The 30-day mortality rate was 10% for women and 2% for men. Older age, being female, and higher comorbidity were independently associated with 30-day mortality rate among PPU patients in Korea. Conclusions: Special attention should be paid to elderly women with high comorbidity who develop PPU. © 2012 by the Japan Epidemiological Association.

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Bae, S. J., Shim, K. N., Kim, N., Kang, J. M., Kim, D. S., Kim, K. M., … Jung, S. W. (2012). Incidence and short-term mortality from perforated peptic ulcer in Korea: A population-based study. Journal of Epidemiology, 22(6), 508–516. https://doi.org/10.2188/jea.JE20120056

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