Application of Platelet Rich Fibrin in the Regeneration of Intra Oral Defects: A Systematic Review

Abstract

Objective: To systematically review the randomized clinical trials (RCTs) on the effect of Platelet Rich Fibrin (PRF) concentrate on the tissue regeneration of intra-oral defects. Methods: An electronic search was performed in PubMed/Medline and Cochrane Library using relevant keywords until June 2018. RCTs which used PRF concentrate for treatment of intrabony defects, sinus augmentation, furcation involvement, endo-periodontal lesions, gingival recession, and ridge preservation were included in the present review. Results: In total, 79 studies that were used PRF either solely or mixed in human trials were included and divided based on the defect type. Most of the studies used PRF to treat intra-bony defects showed that it would improve treatment outcomes. In case of furcation involvement, the application of L-PRF in addition to open flap debridement improved the bone regeneration in grade II mandibular furcation involvement. In case of ridge preservation and sinus floor augmentation, the results were controversial. Conclusions: The result of the current systematic review implied that the treatment outcome of PRF application for periodontal and soft tissue repair depends on the treatment strategies and type of the defect. It was shown to PRF application is a practical approach to accelerate and enhance new bone formation in human studies in intrabony defects and furcation involvements.  However, further clinical trials for evaluation of other types of intra-oral defects are required.