Identifying reproducible individual differences in childhood functional brain networks: An ABCD study

2Citations
Citations of this article
46Readers
Mendeley users who have this article in their library.

Abstract

The 21-site Adolescent Brain Cognitive Development (ABCD) study provides an unparalleled opportunity to characterize functional brain development via resting-state functional connectivity (RSFC) and to quantify relationships between RSFC and behavior. This multi-site data set includes potentially confounding sources of variance, such as differences between data collection sites and/or scanner manufacturers, in addition to those inherent to RSFC (e.g., head motion). The ABCD project provides a framework for characterizing and reproducing RSFC and RSFC-behavior associations, while quantifying the extent to which sources of variability bias RSFC estimates. We quantified RSFC and functional network architecture in 2,188 9-10-year old children from the ABCD study, segregated into demographically-matched discovery (N = 1,166) and replication datasets (N = 1,022). We found RSFC and network architecture to be highly reproducible across children. We did not observe strong effects of site; however, scanner manufacturer effects were large, reproducible, and followed a “short-to-long” association with distance between regions. Accounting for potential confounding variables, we replicated that RSFC between several higher-order networks was related to general cognition. In sum, we provide a framework for how to characterize RSFC-behavior relationships in a rigorous and reproducible manner using the ABCD dataset and other large multi-site projects.

Cite

CITATION STYLE

APA

Marek, S., Tervo-Clemmens, B., Nielsen, A. N., Wheelock, M. D., Miller, R. L., Laumann, T. O., … Dosenbach, N. U. F. (2019). Identifying reproducible individual differences in childhood functional brain networks: An ABCD study. Developmental Cognitive Neuroscience, 40. https://doi.org/10.1016/j.dcn.2019.100706

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free