Comprehensive diagnostic criteria for igG4-related disease

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Although IgG4-related disease (IgG4-RD) is a novel and important disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells, its clinical diagnostic criteria have not been fully established. Many patients with IgG4-RD have lesions in multiple organs, either synchronously or metachronously, and the pathological features of each organ differ. We established comprehensive diagnostic criteria for IgG4-RD for the practical use of specialists and nonspecialists.




Umehara, H., & Okazaki, K. (2014). Comprehensive diagnostic criteria for igG4-related disease. In Igg4-Related Disease (pp. 35–39). Springer Japan.

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