WOUND HEALING PROPERTIES OF GREEN TEA EXTRACT IN EXCISION-WOUNDED RATS

Abstract

The wound healing potential of green tea extract (GTE) was determined in two concentrations (0.6 and 6% in Vaseline base) for topical treatment of excision wounds in rats. Treatments were applied for 14 days. GTE, in both concentrations, caused a significant increase in wound contraction rate and glutathione level, as well as a significant decrease in lipid peroxidation and transforming growth factor-β expression. Moreover, histological examination showed a marked improvement in the skin condition. This study concludes that GTE was effective in enhancing the healing process in excision wounds.