An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma

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Abstract

BACKGROUND: The prognosis of children with metastatic stage 4 neuroblastoma (NB) has remained poor in the past decade.<br /><br />PATIENTS AND METHODS: Using microarray analyses of 342 primary tumors, we here developed and validated an easy to use gene expression-based risk score including 18 genes, which can robustly predict the outcome of stage 4 patients.<br /><br />RESULTS: This classifier was a significant predictor of overall survival in two independent validation cohorts [cohort 1 (n = 214): P = 6.3 × 10(-5); cohort 2 (n = 27): P = 3.1 × 10(-2)]. The prognostic value of the risk score was validated by multivariate analysis including the established markers age and MYCN status (P = 0.027). In the pooled validation cohorts (n = 241), integration of the risk score with the age and/or MYCN status identified subgroups with significantly differing overall survival (ranging from 35 to 100 %).<br /><br />CONCLUSION: Together, the 18-gene risk score classifier can identify patients with stage 4 NB with favorable outcome and may therefore improve risk assessment and treatment stratification of NB patients with disseminated disease.

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Formicola, D., Petrosino, G., Lasorsa, V. A., Pignataro, P., Cimmino, F., Vetrella, S., … Capasso, M. (2016). An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma. Journal of Translational Medicine, 14(1). https://doi.org/10.1186/s12967-016-0896-7

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