Formulation, characterization and evaluation of vildagliptin and metformin combined tablets

Abstract

The current study was conducted to formulate and assess combined vildagliptin (VD) and metformin hydrochloride (MET) tablets. The formulations were developed by wet granulation to overwhelm the reduced compressibility of MET powder. Polymers like Kollidon K30 and K90 were used to prepare formulations. Micromeritics characteristics of blends were assessed. Subsequently, the tablets that had been manufactured were assessed for post-compression characteristics. The composition formula F7 was optimal due to having the best hardness, friability and good dissolution.