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Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen

  • Borisova G
  • Arya B
  • Dislers A
  • et al.
Journal of Virology (1993) 67(6) 3696-3701
DOI: 10.1128/jvi.67.6.3696-3701.1993
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Abstract

A hepatitis B core antigen (HBcAg) gene bearing the 39-amino-acid-long domain A of hepatitis B surface antigen (HBsAg) within the HBcAg immunodominant loop has been constructed and expressed in Escherichia coli. Chimeric capsids demonstrated HBs but not HBc antigenicity and elicited in mice B-cell and T-cell responses against native HBcAg and HBsAg.

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Borisova, G., Arya, B., Dislers, A., Borschukova, O., Tsibinogin, V., Skrastina, D., … Grens, E. (1993). Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen. Journal of Virology, 67(6), 3696–3701. https://doi.org/10.1128/jvi.67.6.3696-3701.1993

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