To evaluate anti-anxiety activity of thymol

Abstract

OBJECTIVETo evaluate anti-anxiety activity of thymol (5, 10, 20 mg/kg. i.p.) in Swiss albino mice.METHODSSix group (n=5) of mice were used in this study. Drug was given to each animal intraperitonealy, behavior testing was performed in animal models after 30 min of all treatment, time spent in light area/open space was observed for 5 min duration (300 s). Significant increase in percentage of time spent in open arms of EPM and significant increase in percentage of time spent in light compartment of LDT indicate anxiolytic-like effect respectively. Significant decreased in above parameters indicates anxiogenic effect.RESULTSThymol 20 mg/kg significantly increased percentage of time spent in open arms of EPM and light compartment of LDT as compared to their vehicle treated group.CONCLUSIONSThymol (20 mg/kg) produced significant anti-anxiety effect as compared to vehicle (0.01% ethanol) treated mice in both EPM and LDT behavioral models.