Ready, set, cleave: Proteases in action

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Activity-based probes are small molecules that can be used to monitor enzyme activity by covalently binding to specific residues in the active site. In this issue of Chemistry & Biology, Lu and colleagues developed a specific fluorescent activity-based probe that targets the papain-like cysteine bacterial type III effector protease AvrPphB and used it to demonstrate the regulation of the protease secretion and pathogenesis. © 2013 Elsevier Ltd.




Salpeter, S. J., & Blum, G. (2013, February 21). Ready, set, cleave: Proteases in action. Chemistry and Biology. Elsevier Ltd.

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