Impact of heparan sulfate chains and sulfur-mediated bonds on the mechanical properties of bovine lens capsule

4Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

We assessed the importance of glycosaminoglycans and sulfur-mediated bonds for the mechanical properties of lens capsules by comparing the stress-strain responses from control and treated pairs of bovine source. No significant change in mechanical properties was observed upon reduction of disulfide bonds. However, removal of glycosaminoglycan chains resulted in a significantly stiffer lens capsule, whereas high concentrations of reducing agent, which is expected to reduce the recently reported sulfilimine bond of collagen IV, resulted in a significantly less stiff lens capsule. A comparison of the diffraction patterns of the control and strongly reduced lens capsules indicated structural rearrangements on a nanometer scale. © 2011 by the Biophysical Society.

Cite

CITATION STYLE

APA

Dyksterhuis, L. D., White, J. F., Hickey, M., Kirby, N., Mudie, S., Hawley, A., … Ramshaw, J. A. M. (2011). Impact of heparan sulfate chains and sulfur-mediated bonds on the mechanical properties of bovine lens capsule. Biophysical Journal, 100(9), 2077–2083. https://doi.org/10.1016/j.bpj.2011.03.020

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free